Just because it's sold over the counter doesn't mean it's entirely safe.

How Much Advil Can You Take? What to Know About Health Risks

July 24, 20252 min read

A client recently asked if it’s okay to take 3 Advil, three times a day. That's 1,800 milligrams of ibuprofen. It’s a great question, and the answer is... it depends.

Ibuprofen (brand names include Advil, Motrin, and Nuprin) is widely used for headaches, period cramps, fevers, back pain, and joint inflammation.

It works by blocking enzymes that cause inflammation and pain, offering quick relief. It’s so effective and easily available that people reach for it without a second thought.

But just because it’s sold over the counter doesn’t mean it’s risk-free.

What’s the Recommended Dosage?

The label on most over-the-counter ibuprofen products recommends a maximum of 1,200 mg per day (six 200 mg tablets)regular-strength tablets).

Doctors may prescribe higher doses (up to 3,200 mg per day) for short-term use after surgery or injury.

These higher doses come with more risk, especially if you’re taking them without medical supervision.

If you're taking more than 1,200 mg daily for more than a few days, talk to your doctor about the benefits and risks, especially if you’re dealing with chronic pain.

What Are the Risks?

Ibuprofen is an NSAID (nonsteroidal anti-inflammatory drug). These medications don’t just block pain, they affect the kidneys, liver, and stomach lining.

Long-term or high-dose use can cause issues in otherwise healthy people:

  • Ulcers or stomach irritation, especially when taken in high doses or on an empty stomach.

  • Kidney and liver stress for people with high blood pressure, cirrhosis, or kidney disease.

  • Increased risk of heart attack or stroke with long-term use, particularly in those with cardiovascular risks.

  • Rebound headaches: regular ibuprofen use can backfire and cause more headaches in people with chronic headaches or migraines.

  • Pregnancy: ibuprofen isn't recommended at or after 20 weeks, due to fetal kidney risk ​.

Other considerations

👉 To avoid stomach upset, take ibuprofen with food.

👉 Ibuprofen can cause you to bleed and bruise more easily.

👉 Beware over the counter "drug cocktails," usually cold and flu meds, that include ibuprofen and could lead to overdose..

Are There Safer Alternatives?

Combining ibuprofen with acetaminophen (Tylenol) in alternating doses can offer more relief with fewer side effects than high doses of either alone.

The synergy between acetaminophen and ibuprofen allows for lower doses of each, potentially reducing side effects while maximizing pain relief.

Acetaminophen comes with its own cautions. It’s metabolized through the liver, so combining it with alcohol or taking it frequently raises safety concerns.

Short-term, ibuprofen is safe for most people at moderate doses. Taking it at high doses for more than a week or two is a signal to dig deeper.

If pain has been around that long, your body is trying to tell you something. Masking it with pills may keep you from addressing the origin of the pain.


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